Telomerase



Telomerase (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 Telomerase Reverse Transcriptase (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, i.e. crystal structure of catalytic subunit of telomerase, TERT, from Tribolium castaneum (3du5).

3D Structures of Telomerase
3kyl, 3du5, 3du6 – TERT+DNA – Tribolium castaneum

2r4g – TtTERT RNA binding domain+RNA – Tetrahymena thermophila

2b2a – TtTERT (mutant)

2fey - TtTERC RNA P2b hairpin – NMR

1q75, 2k96 – hTERC RNA P2b hairpin (mutant) – human – NMR

2k95 - hTERC RNA P2b hairpin – NMR

2qh2 - hTERC RNA CR7– NMR

1na2, 1ymo - hTERC RNAstem loop IV– NMR

1z31 - hTERC RNA Pj6 hairpin – NMR